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KMID : 0376219790160020439
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Chonnam Medical Journal
1979 Volume.16 No. 2 p.439 ~ p.444
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Synergism of antibiotics gentamicin-resistant Pseudomonas aeruginosa
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Abstract
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Measuring the minimum inhibitory concentration (MIC) of gentamicin(GM) against 70 strains of Pseudomonas aeruginosa showed that 6 strains are resistant to GM. These six strains were submitted to the synergistic activity test of carbenicillin (CB) or sulbenicillin (SB) combined with GM or tobramycin (TM) and measured about the MIC of each drug by checkerboard dilution method. The synergism of the antibiotics against each strain was determined by calculating the fractional inhibition concentration index (FICI).
TM MICs of the 6 strains, the GM MIC of which was 40, ,mg/mt, were distributed between 20,mg/ml and 40,mg/ml in half, respectively. Four strains were resistant to CB and SB, while two strains were susceptible.
Addition of GM in the amount of 1/2MIC 20,mg/ml to the medium containing CB or SB brought about a significant effect, but the MIC distribution of drugs combined was different from that of each drug.
Four strains resistant to CB and SB´ were inhibited synergistically by all of the four drug combinations (GM·CB, GM·SB, TM·CB, TM·SB). Two strains susceptible to CB and SB were inhibited synergistically by GM·CB and TM·CB, while were not by GM·SB and TM·SB.
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